Endocrine Abstracts

Introduction: Congenital adrenal hyperplasia (CAH) is a group of rare inherited autosomal recessive disorders, CAH is caused by a mutation in the CYP21A2 gene that leads to a deficiency of 21-hydroxylase (CYP21), due to CYP21A2 gene mutations. Testicular adrenal rest tumors (T-ARTs) is a rare kind of benign tumor in the testis, which occurs mainly secondary to congenital adrenal hyperplasia (CAH). We report a rare case of bilateral TART in a patient with CAH whose diagnosis wa...

Introduction: Hyperparathyroidism is a pathological condition characterized by the excessive secretion of parathyroid hormone (PTH), resulting from the hyperactivity of one or more parathyroid glands. This condition can manifest as primary, secondary, or tertiary hyperparathyroidism. However, determining the primary or tertiary origin of hyperparathyroidism can pose challenges in certain complex situations. In this report, we present a clinical case where identifying the prima...

Introduction: Obesity has become a major health problem and a global epidemic, with a worldwide prevalence that has doubled over the last three decades. According to the WHO, obesity is defined as a body mass index of 30 kg/m2 or more The relationship between obesity and bone capital has been proven. A few years ago, it was thought that obesity had a protective effect on bone, a belief that influenced clinical practice. However, various pathogenic mechanisms, notably vitaminD ...

Introduction: Primary hyperparathyroidism(PHPT) is a prevalent endocrine disorder characterized by hypercalcemia due to the overproduction of parathyroid hormone(PTH) from one or more parathyroid glands. While PHPT is typically diagnosed incidentally through routine laboratory testing due to asymptomatic hypercalcemia, acute pancreatitis as the initial symptom is a rare occurrence. This article presents three cases where acute pancreatitis served as the first manifestation ofP...

Introduction: Hyperparathyroidism is a condition marked by an overproduction of parathyroid hormone (PTH) due to excessive activity in one or more parathyroid glands. It is a prevalent disorder that may manifest as primary, secondary, or tertiary. In this report, we present three clinical cases highlighting intricate scenarios where determining the primary or tertiary origin of hyperparathyroidism proves challenging.Case reports: A 33-year-old female wit...

Background: Primary hyperparathyroidism (PHPT) is a systemic disease caused by lesions of the parathyroid gland, such as parathyroid adenoma, parathyroid hyperplasia, and parathyroid carcinoma. Bone disease is an important complication of hyperparathyroidism. We herein report a rare case of severe bone disease caused by primary hyperparathyroidism.Case report: A 33-year-old female patient presented with a history of right lower limb pathological fracture...

Introduction: While hypercalcemia is extensively studied in cancer patients, the occurrence of hypocalcemia is not as commonly reported. The unique aspect of this case lies in severe hypocalcemia against the background of a malignant tumor of the cervix, a condition often associated with hypercalcemia.Case report: A 66-year-old patient, diabetic for 13 years with insulin therapy, is being treated for poorly differentiated squamous cell carcinoma of the c...

Introduction: Fournier’s gangrene is a rare and serious poly-microbial necrotizing fasciitis of the perineum and external genitalia, characterized by a fulminant evolution and a high morbidity and mortality. Annual incidence is between 1.6 and 3.3 cases/100,000 patients, with type 2 diabetics accounting for 30% to over 50% of cases, and 66% in women. Observations:Case 1: 48-year-old female, diabetic for 8 years on Metformin, a...

Introduction: According to numerous studies, mesenchymal stem cell therapy is one of the best therapeutic approaches for the treatment of type 1 diabetes. The aim of our study is to provide an update on the contribution of mesenchymal stem cells to glycaemic control and the screening of short-and long-term side effects.Results: We included 5 patients who met our inclusion criteria. The mean age was 21.2 years, with a sex ratio of 0.6. The average duratio...

Introduction: Non-arteritic anterior ischemic optic neuropathy (NOIAN) is acute ischemia of the optic nerve head. It is one of the most common causes of blindness in diabetic patients, especially in the elderly. Visual impairment in NAION may be due to deterioration in visual acuity (VA) and/or visual field (VF) loss. Observation: 51-year-old female patient, diabetic for 14 years on insulin, not well controlled, and hypertensive for 15 years on treatment...